Advanced paternal age directly impacts mouse embryonic placental imprinting
نویسندگان
چکیده
منابع مشابه
Advanced paternal age and reproductive outcome.
Women have been increasingly delaying the start of motherhood in recent decades. The same trend is seen also for men. The influence of maternal age on fertility, chromosomal anomalies, pregnancy complications, and impaired perinatal and post-natal outcome of offspring, has been thoroughly investigated, and these aspects are clinically applied during fertility and pregestational counseling. Male...
متن کاملPossible Role of Paternal Aberrant Imprinting in Placental Development: A Study in Tamoxifen Treatment Rat Model
Genomic imprinting is known to regulate fetal growth and development. Studies from our laboratory have demonstrated that treatment of adult male rats with tamoxifen increased post-implantation loss around mid-gestation. Microarray analysis of resorbing vs. normal embryos revealed aberrant expression of imprinted genes and deregulation of genes associated in placental function. In the present st...
متن کاملPaternal age, placental weight and placental to birthweight ratio: a population-based study of 590,835 pregnancies.
STUDY QUESTION Is the age of the father associated with placental weight or the ratio of placental weight to birthweight? SUMMARY ANSWER Placental weight and placental to birthweight ratio increased according to increasing paternal age, also after adjustment for maternal age. WHAT IS KNOWN ALREADY High paternal age and also high placental to birthweight ratio have been associated with adver...
متن کاملAdvanced paternal age is associated with lower facial attractiveness
a r t i c l e i n f o In view of disease risk, Kong et al. (2012) demonstrated that most of the new mutations are explained by the age of the father at conception. Accordingly, paternal age effects have been found for a variety of offspring traits, from physical and mental health to intelligence. Here, we investigated whether facial attractiveness is significantly associated with paternal age. ...
متن کاملThe effects of advanced paternal age on fertility.
Modern societal pressures and expectations over the past several decades have resulted in the tendency for couples to delay conception. While women experience a notable decrease in oocyte production in their late thirties, the effect of age on spermatogenesis is less well described. While there are no known limits to the age at which men can father children, the effects of advanced paternal age...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: PLOS ONE
سال: 2020
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0229904